Bacurau, a small town in the Brazilian sertão, mourns the loss of its matriarch, Carmelita, who lived to be 94. Days later, its inhabitants notice that their community has vanished from most maps.

Shortly after failing to rescue a drowning man, Donato meets Konrad, a friend of the victim. They soon begin a relationship which seems doomed from the start, while Donato's past catches up with him.

The story of the decline of the Soares family in the final months of the 19th century. Isabel is the dying mother, and her daughters are Maria and Ana. The three women try hard to forget about their pasts in the coffee farm and face the industrial times that start to take over Brazil.